How Modern Doctors Are Treating Depression Without Medication

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This article was medically reviewed by Dr. Troy Noonan, MD Psychiatry. Dr. Noonan received his M.D. from Finch University at the Chicago Medical School, Psychiatry Residency and fellowship at the University of South Florida (USF) College of Medicine. He is Certified by the American Board of Psychiatry & Neurology.

Treating Depression Without Medication

If you’re searching for answers about treating depression without medication, you’re not alone.

You want a simple and inexpensive way to feel good again. Maybe you’ve tried medications, but it’s become obvious that you need a better long-term solution. Many people just like you are searching for the same thing.

The CDC website tells us that depression is a leading cause of disability worldwide and a contributor to the overall burden of disease. Worldwide, more than 264 million people of all ages suffer from depression, with about 16 million U.S. adults suffering major depression.

While antidepressants can provide relief, about 33% of the people who use them will continue to experience symptoms.

“Usually an antidepressant that’s worked for a patient will keep working,” says Paul Nestadt, M.D., psychiatrist and co-director of the Anxiety Disorders Clinic at Johns Hopkins. “But sometimes, a new episode of depression might come up that’s not as responsive to that medication, or the medication might just stop working altogether.”

What Dr. Nestadt is describing is called “treatment-resistant depression” (TRD) or “refractory depression.” Treatment-resistant depression is fairly common and can persist for months or even years. Add to this the common side effects, like nausea, weight gain, and insomnia, and the price of antidepressants, and it’s not surprising that people are searching for alternatives.

This article explains which drugs are commonly used to treat depression, why they sometimes don’t work, and how modern doctors are treating depression without medication.

What Drugs Are Used to Treat Depression?

Depression medications (antidepressants) act on specific neurotransmitters to reduce or eliminate certain symptoms of depression. A neurotransmitter is a specialized chemical that carries “messages” from one neuron (nerve cell) to another. They control everything from muscle movement, gland activation, hormone release, and mood.

Neurotransmitters come in two basic types: excitatory, and inhibitory. In layman’s terms, excitatory neurotransmitters are your “get up and go” neurotransmitters while inhibitory neurotransmitters are your “rest and relax” neurotransmitters.

Excitatory neurotransmitters promote brain signals that lead to an increase in brain and nervous system activity while inhibitory neurotransmitters block certain brain signals in order to decrease activity in the brain and nervous system.

For example, norepinephrine (also called “noradrenaline”) is a well-known excitatory neurotransmitter. A sudden burst of norepinephrine energizes your brain and nervous system. It can cause feelings of euphoria, but is also associated with elevated blood pressure, hyperactivity, and panic attacks.

Treating depression without medication - Neurotransmitters
Synapse and Neuron cells sending electrical chemical signals

Low levels of norepinephrine can cause brain fog (lack of concentration), attention deficit hyperactivity disorder (ADHD), lethargy, and even depression. This is why some antidepressants (which we’ll discuss soon) are designed to increase norepinephrine levels.

GABA, on the other hand, is an inhibitory neurotransmitter that acts to block or slow certain nerve signals. It influences how you experience stress, anxiety, and fear by relaxing the “fight or flight” functions of your nervous system. Low levels of GABA can cause a variety of mental health problems, a common one being anxiety disorder.

The complex interaction between excitatory and inhibitory neurotransmitters helps to stabilize fluctuations between your “fight or flight” and “rest and digest” states. Too much, or too little, of any neurotransmitter can upset this balance, leading to abnormal fluctuations between these states or to prolonged periods of anxiety, depression, hypervigilance, etc.

Depression is characterized by abnormally low levels of specific excitatory neurotransmitters. Antidepressants seek to solve this problem by promoting the levels and the activity of these neurotransmitters. The most common medications for treating depression include:

#1: Serotonin Reuptake Inhibitors

The two most common Serotonin Reuptake Inhibitors are Selective Serotonin Reuptake Inhibitors (SSRIs) and Selective Serotonin Noradrenaline Reuptake Inhibitors (SSNRIs). SSRIs are the most prescribed antidepressants.

Serotonin Reuptake Inhibitors act on the neurotransmitter called serotonin. Serotonin is a neurotransmitter that can function as an excitatory or inhibitory neurotransmitter. It plays a vital role in multiple brain and nervous system activities, one of which is mood regulation. Serotonin deficiency is associated with multiple psychiatric disorders, the most common being depression.

Both SSRI and SSNRI increase serotonin levels in your brain, but SSNRI also impacts norepinephrine levels. Common SSRI side effects may include headache, nausea, vomiting, nervousness, dry mouth, restlessness, reduced sexual desire, erectile dysfunction, drowsiness, insomnia, loss of appetite, and weight fluctuations.

#2: Tricyclic Antidepressants (TCAs)

TCAs are another commonly prescribed antidepressant. They act to increase serotonin levels and norepinephrine levels while blocking the neurotransmitter, acetylcholine. Acetylcholine is an excitatory neurotransmitter associated with increased stress, anxiety, and depression.

Side effects of TCAs may include, dry mouth, lowered blood pressure when moving from sitting to standing, urine retention, drowsiness, blurry vision, increased appetite, constipation, tremors, excessive sweating, erectile dysfunction, low sex drive, and difficulty achieving orgasm.

#3: Bupropion

Bupropion acts on two neurotransmitters: norepinephrine and dopamine. Dopamine is an excitatory neurotransmitter that is often called your “reward chemical.” It plays a key role in attention, motivation, learning, movement, pain processing, and mood regulation. It also influences heart rate, blood vessel dilation, sleep patterns, and kidney function.

While increased levels of dopamine can cause anxiety, low dopamine levels can also create a multitude of physical and mental deficiencies, a few being: insomnia, low energy, brain fog (lack of concentration), lack of focus, slower movement or speech, lack of motivation, sadness, low self-esteem, and hopelessness.

Bupropion is less effective for treating depression when the depression is coupled with symptoms of anxiety. Side effects of Bupropion might include: dry mouth, insomnia, irritability, restlessness, tremors, anxiety, hyperventilation, and irregular heartbeat.

#4: Monoamine Oxidase Inhibitors (MAOIs)

MAOIs inhibit the breakdown of three neurotransmitters: serotonin, norepinephrine, and dopamine. Inhibiting the breakdown of these neurotransmitters increases their concentration in the brain. Side effects of MAOIs might include: headache, dry mouth, insomnia, nausea, diarrhea, constipation, dizziness, lightheadedness.

Less common side effects might include: low blood pressure, involuntary muscle spasms, reduced sexual desire, trouble achieving orgasm, difficulty urinating, muscle cramps, and paresthesia (tingling sensations in the skin).

#5: Esketamine

Esketamine increases levels of glutamate with the goal of providing relief from depression symptoms within just a few minutes. Glutamate is the most abundant excitatory neurotransmitter in the brain and plays a key role in brain function, including the process of learning new information through the strengthening of neural connections.

Common side effects of esketamine may include: headache, lightheadedness, confusion (about identity, time, and place), anxiety, dizziness, blurred vision, drowsiness, feeling of self or surroundings being in constant motion, feelings of unreality, nervousness, pounding in ears, detachment from self, slow or fast heartbeat, dullness, tiredness, weakness, or feeling of sluggishness.

Less common side effects might include: changes in speech patterns or rhythms of speech, abnormal sense of well-being, irregular heartbeat or pulse, nightmares or abnormally vivid dreams, slurred speech, frequent daytime urination, and trouble urinating.

Why Antidepressants Don’t Always Work

Treating depression without medication - why medications don't workThere’s no easy explanation for why some depression medications either don’t work, or will work for a time and then stop.

The antidepressants mentioned above act on neurotransmitters with the goal of mitigating or eliminating the symptoms of depression. However, as mentioned earlier, one third of the people who take these medications will only experience temporary relief or continue to experience the symptoms of depression.

These people are left searching for information on treating depression without medication. Sometimes, this means figuring out why their medication stopped working. However, Paul Nestadt, M.D., psychiatrist and co-director of the Anxiety Disorders Clinic at Johns Hopkins, reminds us even the research is unclear on this question:

“There’s no good research that shows why a medication may stop working for someone,” says Dr. Nestadt. “I think it’s less an issue of building up tolerance and more likely constantly changing stressors and factors in the brain.”

Here are some common speculations what might cause these “changing stressors and factors in the brain” and render a medication ineffective:

#1: Competing Medications

Patients taking multiple medications might continue to experience depression as a side effect of those other medications. Certain combinations of prescription drugs can also produce side effects similar to the symptoms of depression.

When this happens, it can be hard for the patient to determine whether the competing medications are causing the persistent symptoms, or interfering with the antidepressants. This is why it’s a good idea to consult with your medical provider before searching for means of treating depression without medication.

#2: Other Medical Problems

Patients with other medical problems (aside from depression) might continue to experience depression because of the other unresolved conditions. Other times, the symptoms of the other medical problems might elicit a depression diagnosis, when depression is merely a symptom of something else.

For example, depression shares symptoms with another common condition called “Hypothyroidism.” Hypothyroidism is when your thyroid gland (a key gland for controlling your metabolism) isn’t producing enough of the crucial hormones which regulate metabolic function. Some symptoms of hypothyroidism might include: weight gain, fatigue impaired memory, muscle weakness, and depression.

#3: Alcohol and Drug Use

Treating depression without medication - antidepressantsAlcohol and illegal drugs can cause strong mood changes, making it hard for antidepressants to work as intended. Other times, the illegal drug can interfere with the same neurotransmitters that the antidepressant acts on.

For example, cocaine acts on three of the neurotransmitters which are associated with depression: dopamine, norepinepherine, and serotonin. The “high” experience associated with cocaine use comes from a spike in these three neurotransmitters.

However, the “coming down” period can cause deep periods of temporary depression because of these neurotransmitter levels being exhausted.

Long term cocaine use can also cause resistance to these three neurotransmitters, thus inhibiting their effectiveness. This is simply one example. Other illegal drugs can have similar effects on neurotransmitters and hormones, rendering antidepressants less effective.

#4: Pregnancy or Menopause

Pregnancy and menopause dramatically impact hormone levels. Pregnancy also causes increases in body weight and blood volume, both of which can change the required dosage for a drug and affect its impact on the patient. Women who are pregnant or experiencing menopause should consult their medical care providers about these factors before starting or changing a depression medication.

#5: Stress

Depression is both biological and psychosocial (combination of psychological and social factors). The biological factors of depression are characterized by measurable changes in the neurotransmitters which influence emotions and moods.

However, these biological factors can also be triggered, enhanced, or prolonged as a result of lifestyle stress. The death of a loved one, loss of a job, a new stressor at home or work, or a sudden personal crisis can cause sudden changes in mood that seem to eclipse the effects of depression medication.

If you’re searching for answers about treating depression without medication, you might consider some ways to manage these external stressors better. Some of the most effective methods for long-term and short-term stress management include: exercise, healthier diet, therapy, journaling, meditation, music therapy, or finding a relaxing hobby.

While two thirds of patients experience success with one of the above medications, treatment-resistant depression leaves one third of patients searching for something better. That’s why some modern doctors are using an alternative method for treating depression without medication.

Treating Depression Without Medication

Treating depression without medication - TMS therapy

The internet is full of advice about treating depression without medication. Most of it focuses only on the psychosocial aspects of depression or is based in unproven theories about positive thinking and self-esteem. Few things are more frustrating than having some random blogger tell you that you can will your way out of depression or that you can beat it by positive thinking or meditation.

Dr. Robert Morris Sapolsky, an author, neuroendocrinology researcher and professor of biology, neurology and neurological sciences at Stanford University, says that depression is an illness that is just as biologically real and valid as diabetes.

This is why any sane solution for treating depression without medication must be based on sound biological and measurable methods. Transcranial Magnetic Stimulation (TMS) is such a method by which modern doctors are treating depression without medication.

TMS is a safe, painless, noninvasive procedure that stimulates nerve cells in the brain using magnetic fields, similar to the magnetics used in MRIs. Patients can literally drive themselves to the doctor on their lunch break, get treated, drive back to work and have a normal and productive day.

Treatment cycles typically last six to eight weeks (including five 20-minute treatments per week), after which most patients experience lasting relief from the symptoms of severe depression.

As of August 2021, four million people in the United States have undergone TMS treatment and hundreds of medical practices across America are treating depression without medication using TMS. Unlike antidepressants, TMS doesn’t come with a lengthy list of complicated side-effects.

Controlled clinical trials have found that 83% of Neurostar TMS patients see a positive response with only an 11% relapse rate across all study patients. Only 37% of patients required more TMS, and 85% of these patients re-achieved a clinical benefit.

Why Haven’t I Heard About TMS Before?

This is a common question, and a good one. The answer has little to do with TMS and more to do with the complicated nature of the healthcare system and the medical insurance industry. Most patients require their medical insurance provider to cover the bulk of the cost for the TMS treatments. Major medical insurance companies require patients to prove that their depression is truly treatment resistant before the insurance company will agree to cover TMS treatment.

Thankfully, this process isn’t as complicated as it sounds, and medical practices offering TMS have become efficient at leading new patients through it. The hope is that more positive patient experiences and clinical studies will eventually persuade insurance companies to cover TMS at the start of a patient’s treatment.

Learn More About Treating Depression Without Medication

Treating depression without medication - Neurostar TMSAre you looking for a simple and inexpensive way to be free of depression and to live a happier and more productive life?

If so, Mental Health Management Group would like to help you learn more about what TMS will do for you. Their doctors have helped patients successfully manage dozens of complex mental illness and behavior disorders.

Mental Health Management Group would routinely helps people achieve things which would have been impossible while suffering from mental illness. They’ve helped troubled teens graduate high school and we’ve helped adults (young and older) graduate college. Mental Health Management Group patients have become artists, musicians, doctors, lawyers, and much more.

Our doctors have been practicing since 1996 and have treated hundreds of patients with depression and other mental health challenges. They have two certified TMS technicians and a friendly administration staff that can help you with the complicated process of meeting the TMS qualifications for your insurance provider.

When you become a patient at Mental Health Management Group would, you can be confident that you’re in the hands of true professionals who helped hundreds of people just like you feel good and enjoy a happy and fulfilling life. To see if you or a family member qualify for TMS treatment, please fill out the patient referral form and one of our practitioners will call you. This will help you better understand if TMS is right for you.

This concludes our article on Treating Depression Without Medication.

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